Symbol
Name
ID

Spp1
secreted phosphoprotein 1
MGI:98389

Phenotype annotations related to cardiovascular system

Darker colors indicate more annotations

Human Phenotypes	Vasculitis	Lymphadenopathy	Splenomegaly	Hepatosplenomegaly
Disease(s) Associated with SPP1	Vasculitis	Lymphadenopathy	Splenomegaly	Hepatosplenomegaly
biliary atresia
multiple myeloma
pancreatic cancer
rheumatoid arthritis

Mouse Phenotypes

abnormal blood vessel morphology

decreased susceptibility to atherosclerosis

abnormal physiological neovascularization

decreased heart weight

calcified aortic valve cusp

abnormal cardiovascular system physiology

abnormal blood flow velocity

eye hemorrhage

decreased cardiac muscle contractility

increased heart rate

abnormal response to cardiac infarction

decreased systemic arterial blood pressure

decreased systemic arterial systolic blood pressure

abnormal blood vessel physiology

abnormal vasodilation

abnormal vascular wound healing

Availability

Mouse Genotype

Spp1^{tm1.1(KOMP)Vlcg}/Spp1^{tm1.1(KOMP)Vlcg}

Spp1^tm1Blh/Spp1^tm1Blh

Spp1^tm1Rit/Spp1^tm1Rit

Spp1^tm1Blh/Spp1⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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